DCC-Interacting Protein 13-Beta (APPL2) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
DCC-Interacting Protein 13-Beta (APPL2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036769
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the APPL2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DCC-Interacting Protein 13-Beta (APPL2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | DIP13B,Dip13-beta,Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 |
| Background | Antibody anti-APPL2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
APPL2 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 2) is another member of the APPL protein family, similar to APPL1. Like APPL1, APPL2 also contains a pleckstrin homology (PH) domain and a leucine zipper, enabling it to interact with phosphotyrosine-containing proteins. APPL2 is involved in a wide range of cellular processes including endocytosis, signal transduction, and the regulation of vesicular trafficking. It is particularly important in regulating the function of the insulin receptor and in modulating signaling pathways that control cell growth, survival, and metabolism. APPL2 is known to affect cellular responses to growth factors and contributes to the regulation of neuronal function and plasticity. Its role in intracellular signaling makes it a relevant protein in understanding diseases like diabetes and neurodegenerative conditions.
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