Damage Specific DNA Binding Protein 2 (DDB2) Antibody
273€ (100 µl)
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Name
Damage Specific DNA Binding Protein 2 (DDB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx130944
Description
DDB2 Antibody is a Rabbit Polyclonal against DDB2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Damage Specific DNA Binding Protein 2 (DDB2) Immunogen: DDB2 (Lys212-Leu407) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | XPE,DDBB,UV-DDB2,UV-damaged DNA-binding protein 2,Damage-specific DNA-binding protein 2,DDB p48 subunit |
| Background | Antibody anti-DDB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Damage-specific DNA binding protein 2 (DDB2) is a substrate recognition protein that works in concert with DDB1 within the UV-DDB complex, a subset of the CUL4-DDB1 E3 ubiquitin ligase system. DDB2 plays an essential role in nucleotide excision repair (NER) by recognizing UV-induced DNA damage, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts, and recruiting repair factors to the damage site. Its high affinity for damaged DNA and ability to induce chromatin remodeling are key to facilitating repair processes. DDB2 also mediates the ubiquitination and degradation of histones and other chromatin-associated proteins, promoting access to damaged DNA. Mutations or dysregulation of DDB2 have been linked to xeroderma pigmentosum group E (XP-E), a condition characterized by extreme sensitivity to UV light and a high predisposition to skin cancer. Beyond DNA repair, DDB2 is implicated in cell cycle regulation and apoptosis, highlighting its multifunctional role in maintaining genomic integrity.
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