Cytosolic Carboxypeptidase 2 (AGBL2) Antibody
357.5€ (100 µg)
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Name
Cytosolic Carboxypeptidase 2 (AGBL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx036675
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the AGBL2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cytosolic Carboxypeptidase 2 (AGBL2) Immunogen: Recombinant fragment corresponding to 63-281 AA of human AGBL2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 104 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CCP2 |
| Background | Antibody anti-AGBL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGBL2 is another tubulin-modifying enzyme that regulates microtubule stability by cleaving polyglutamate chains from tubulin. It is expressed in various tissues, including the brain, where it contributes to neuronal function, axonal transport, and synaptic organization. AGBL2 plays a role in neurodegenerative diseases, with studies linking its dysregulation to tauopathies, including Alzheimer's disease, where abnormal polyglutamylation of microtubules contributes to neuronal dysfunction. In addition to its neural roles, AGBL2 has been implicated in cancer, where it modulates cell division and migration through its influence on the cytoskeleton.
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