Cytokeratin 18 (CYK18) Antibody
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Description
Cytokeratin 18, also known as CK18, CYK18, KRT18.Entrez Protein NP_000215.It encodes the type I intermediate filament chain keratin 18.Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family.They are expressed in single layer epithelial tissues of the body.Mutations in this gene have been linked to cryptogenic cirrhosis.Two transcript variants encoding the same protein have been found for this gene.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cytokeratin 18 (CYK18) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05783 |
| Gene ID | 3875 |
| OMIM | 148070 |
| Background | Antibody anti-KRT18 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
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Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas.
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