Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody
416€ (200 µl)
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name
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433617
tested applications
P-ELISA, IHC
Description
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody is a Goat Polyclonal against Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Size 1 | 200 µl |
| Tested Applications | P-ELISA, IHC |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 1080 |
| NCBI Accession | NP_000483.3 |
| Alias | ATP-binding cassette sub-family C member 7,CF,MRP7,ABC35,ABCC7,CFTR/MRP,TNR-CFTR,dJ760C5.1,Cystic fibrosis transmembrane conductance regulator,Channel conductance-controlling ATPase |
| Background | Antibody anti-CFTR |
| Status | RUO |
Descripción
CF Transmembrane Conductance Regulator (ABCC7), widely known as the cystic fibrosis transmembrane conductance regulator (CFTR), is a chloride channel essential for maintaining ion and water balance across epithelial cell membranes. Mutations in the CFTR gene cause cystic fibrosis (CF), a life-threatening genetic disorder that leads to thick mucus buildup in the lungs, pancreas, and other organs. As an ATP-gated channel, ABCC7 regulates chloride and bicarbonate secretion, influencing fluid viscosity and pH in various tissues. Beyond ion transport, CFTR modulates inflammation and immune responses, contributing to its broader physiological significance. Therapeutic interventions targeting CFTR, such as small-molecule modulators, have revolutionized CF management, improving lung function and quality of life for many patients. Additionally, CFTR dysfunction has been implicated in other conditions like chronic obstructive pulmonary disease (COPD) and pancreatitis, underlining its relevance in diverse respiratory and gastrointestinal diseases.
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