Cysteinyl Leukotriene Receptor 1 (CYSLTR1) Antibody (HRP)
169€ (20 µg)
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Name
Cysteinyl Leukotriene Receptor 1 (CYSLTR1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx303570
Tested Applications
ELISA
Description
CYSLTR1 Antibody (HRP) is a Rabbit Polyclonal against CYSLTR1 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cysteinyl Leukotriene Receptor 1 (CYSLTR1) Immunogen: Recombinant human Cysteinyl leukotriene receptor 1 protein (298-337AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y271 |
| Gene ID | 10800 |
| OMIM | 300201 |
| Alias | CYSLTR1,CYSLT1,CYSLT1R,CYSLTR,HMTMF81,HG55,LTD4,leukotriene D4 receptor |
| Background | Antibody anti-CYSLTR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CYSLTR1 is a G protein-coupled receptor (GPCR) that binds cysteinyl leukotrienes (CysLTs), including leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4). It is highly expressed in smooth muscle cells, mast cells, eosinophils, and airway epithelial cells. CYSLTR1 signaling plays a central role in allergic and inflammatory responses, particularly in asthma and allergic rhinitis, where it mediates bronchoconstriction, vascular permeability, and mucus production. Activation of CYSLTR1 triggers the phospholipase C (PLC) pathway, leading to calcium mobilization and smooth muscle contraction. CYSLTR1 is also implicated in chronic inflammatory diseases such as atopic dermatitis and cardiovascular disorders. Its overactivation exacerbates tissue damage, airway hyperresponsiveness, and immune cell recruitment. Leukotriene receptor antagonists (LTRAs), such as montelukast and zafirlukast, target CYSLTR1 and are used clinically to manage asthma and allergic inflammation by blocking cysteinyl leukotriene signaling. CYSLTR1 remains a critical therapeutic target for allergic and inflammatory diseases.
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