Cow Somatostatin receptor type 2 (SSTR2) ELISA Kit
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Description
Cow Somatostatin receptor type 2 (SSTR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Somatostatin receptor type 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Somatostatin receptor type 2 (SSTR2) |
| Reactivity | Cow |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P34993 |
| Alias | SSTR2,somatotropin release-inhibiting factor receptor,SRIF-1,SST2 |
| Background | Elisa kits for SSTR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SSTR2 is another member of the somatostatin receptor family, primarily activated by somatostatin. Like SSTR1, SSTR2 also couples to Gi proteins to inhibit adenylate cyclase and reduce cAMP levels. It is expressed in a variety of tissues, including the pituitary gland, pancreas, and gastrointestinal tract, and plays a crucial role in regulating the secretion of growth hormone, insulin, and other hormones. SSTR2 is particularly important in inhibiting the release of growth hormone from the pituitary and in controlling insulin release from pancreatic β-cells. It is also implicated in regulating gastrointestinal motility and digestive enzyme secretion. Dysregulation of SSTR2 signaling is often found in tumors, particularly neuroendocrine tumors, where increased hormone secretion occurs. SSTR2 agonists, like somatostatin analogs, are used in the clinical management of conditions such as acromegaly, carcinoid syndrome, and other endocrine-related disorders, where they help control hormone levels and reduce tumor growth.
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anti- SSTR2 antibody
Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
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