Cow Mu-type opioid receptor (OPRM1) ELISA Kit
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Description
Cow Mu-type opioid receptor (OPRM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Mu-type opioid receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Mu-type opioid receptor (OPRM1) |
| Reactivity | Cow |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P79350 |
| Alias | OPRM1,Mu receptor,MOP,OP3,MOPr,opioid receptor,mu 1,opioid receptor,MOR,LMOR,MOR1,OPRM,M-OR-1 |
| Background | Elisa kits for OPRM1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
OPRM1, or the mu-opioid receptor, is the primary target for endogenous opioid peptides like endorphins and exogenous opioids such as morphine, fentanyl, and heroin. OPRM1 is highly expressed in pain-processing regions of the CNS, including the brainstem, thalamus, and spinal cord, where it mediates analgesia, euphoria, and sedation. OPRM1 couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to decrease neuronal excitability and neurotransmitter release. Activation of OPRM1 produces potent analgesic effects but also carries risks of tolerance, dependence, and respiratory depression. Dysregulation of OPRM1 signaling is central to opioid addiction, chronic pain, and reward pathways. Selective modulation of OPRM1 has therapeutic potential for improving pain management while reducing side effects such as tolerance and dependence. Biased agonists that preferentially activate analgesic pathways over adverse effects are under development to enhance safety. OPRM1 remains a key target for opioids and therapies addressing addiction and pain disorders.
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Mu-Type Opioid Receptor (OPRM1) Antibody
OPRM1 Antibody is a Rabbit Polyclonal antibody against OPRM1. This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
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