Cow Melanocyte-Stimulating Hormone Receptor (MC1R) ELISA Kit
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Description
Cow Melanocyte-Stimulating Hormone Receptor (MC1R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Melanocyte-stimulating hormone receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Melanocyte-Stimulating Hormone Receptor (MC1R) |
| Reactivity | Cow |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 1-3 weeks. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P47798 |
| Alias | MC1R,CMM5,MSH-R,SHEP2,melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
| Background | Elisa kits for MC1R |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
MC1R is a G protein-coupled receptor (GPCR) activated by melanocortin peptides, including α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). It is primarily expressed in melanocytes, where it regulates skin and hair pigmentation by stimulating the production of eumelanin (dark pigment) through the cAMP pathway. MC1R activation increases intracellular cyclic AMP (cAMP), activating protein kinase A (PKA) and leading to the upregulation of melanin synthesis. Variations and mutations in MC1R are associated with pigmentation phenotypes, such as red hair, fair skin, and an increased susceptibility to UV-induced skin damage and melanoma. Beyond pigmentation, MC1R plays roles in anti-inflammatory responses, immune modulation, and DNA repair, where its activation reduces inflammation and oxidative stress. MC1R agonists are being explored as therapeutic options for UV protection, melanoma prevention, and anti-inflammatory therapies. Its multifaceted role in pigmentation, inflammation, and cancer underscores MC1R’s significance as a therapeutic target.
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