935106861
info@markelab.com
Precio
687.5€ (96 tests)
Cow Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Lysophosphatidic acid receptor 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
LPAR1 is a G protein-coupled receptor activated by lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse cellular processes. LPAR1 is widely expressed in various tissues, including the brain, lungs, and fibroblasts, where it mediates cell proliferation, survival, migration, and cytoskeletal reorganization. LPAR1 couples to multiple G proteins (Gi, Gq, and G12/13), activating pathways such as MAPK, Rho/ROCK, and PI3K/Akt. In fibrosis, LPAR1 signaling promotes fibroblast activation and extracellular matrix deposition, contributing to pulmonary, hepatic, and renal fibrosis. It is also implicated in neuropathic pain, where LPAR1 activation sensitizes pain pathways and amplifies neuronal signaling. In cancer, LPAR1 drives tumor growth, metastasis, and angiogenesis, particularly in breast and lung cancers. Dysregulation of LPAR1 is associated with inflammatory disorders, cancer progression, and fibrosis. LPAR1 antagonists are being developed as potential therapies for fibrotic diseases, neuropathic pain, and cancer, highlighting its role as a key modulator of cell migration and tissue remodeling.
ELISA Kits
Lysophosphatidic Acid Receptor 1 (LPAR1)
Cow
0.156 ng/ml - 10 ng/ml
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
LPAR1,EDG2,LPA1,VZG1,edg-2,vzg-1,Gpcr26,Mrec1.3,rec.1.3,GPR26,endothelial differentiation gene 2,lysophosphatidic acid G-protein-coupled receptor, 2,LPA receptor 1,lysophosphatidic acid receptor Edg-2
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
LPAR1
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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