Cow L-Selectin / CD62L (SELL) Protein
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935106861
info@markelab.com
Precio
2197€ (1 mg)
Protein SELL
proveedor
Abbexareference
abx655021Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Cow Selectin, Leukocyte (SELL) Protein is a Recombinant Cow protein expressed in E. coli.
Background
Selectin L (SELL), commonly known as L-selectin, is a cell adhesion molecule that belongs to the selectin family, which includes three primary members: L-selectin (SELL), E-selectin (SELE), and P-selectin (SELP). L-selectin plays a crucial role in immune surveillance and inflammatory responses, primarily facilitating the interaction between leukocytes (white blood cells) and endothelial cells. SELL is expressed constitutively on most leukocytes, including neutrophils, monocytes, T lymphocytes, B lymphocytes, and natural killer (NK) cells. It is essential for the initial steps of leukocyte extravasation, where leukocytes migrate from the bloodstream to peripheral tissues to respond to infection or injury. SELL mediates leukocyte rolling on the endothelium, an essential part of the immune cell recruitment cascade during inflammation and immune surveillance. It is involved in homing of lymphocytes to secondary lymphoid organs, such as lymph nodes, and facilitates the recruitment of leukocytes to sites of inflammation. SELL’s primary ligands include sialyl Lewis X (sLeX) and GlyCAM-1 (glycan-bearing cell adhesion molecule-1), which are expressed on endothelial cells. The role of L-selectin in trafficking leukocytes to lymphoid tissues is vital for maintaining immune homeostasis and responding to pathogens.
Características del producto
category
Proteins and Peptides
origin
Cow
host
E. coli
immunogen target
L-Selectin / CD62L (SELL)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SELL
dry ice
No
availability
Shipped within 1-2 months.
alias
TQ1,LAM1,LEU8,LNHR,LSEL,CD62L,LYAM1,PLNHR,LECAM1,L-selectin,CD62 antigen-like family member L,Leukocyte adhesion molecule 1,Leukocyte surface antigen Leu-8,Leukocyte-endothelial cell adhesion molecule 1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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