935106861
info@markelab.com
Precio
687.5€ (96 tests)
Cow Docking protein 2 (DOK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow DOK2 concentrations in serum, plasma and other biological fluids.
Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.
ELISA Kits
Docking protein 2 (DOK2)
Cow
0.156 ng/ml - 10 ng/ml
Quantitative
Colorimetric
Serum,Plasma,Other biological fluids
96 tests
Downstream of tyrosine kinase 2,p56DOK,p56dok-2
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
DOK2
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly o...
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