DOK2 antibody
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Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | docking protein 2, 56kDa (DOK2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 56kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O60496 |
| Gene ID | 9046 |
| Alias | Downstream of tyrosine kinase 2,p56DOK,p56dok-2 |
| Background | Antibody anti-DOK2 |
| Status | RUO |
| Note | Mol. Weight 56 kDa |
Descripción
Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.
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