Cow Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Enzyme (Active)
273€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Cow Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Enzyme (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073006
Description
Cow Alkaline Phosphatase Enzyme is a native Cow enzyme isolated from calf intestine.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Intestinal-Type Alkaline Phosphatase / IAP (ALPI) |
| Host | Cow |
| Assay Type | Activity: Active Biological Activity: > 1500 U/mg (at pH 9.6, 25 °C, in 0.025 M glycin, 10% glycerol buffer) |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Cow |
| Expression | Native |
| Purity | 95% (Gel Filtration) |
| Purification | Purified from calf intestine by affinity chromatography. |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Size 3 | 30 mg |
| Form | Liquid |
| Buffer | 5 mM Tris, pH 7.0, containing 5 mM MgCl2, 0.1 mM ZnCl2, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P19111 |
| Alias | IAP |
| Background | Protein ALPI |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Intestinal-type alkaline phosphatase (ALPI) is a glycoprotein enzyme primarily expressed on the luminal surface of intestinal epithelial cells, particularly in the small intestine. It plays a crucial role in maintaining gut homeostasis by detoxifying lipopolysaccharides (LPS), dephosphorylating inflammatory mediators, and promoting a healthy microbiota. ALPI is also involved in nutrient absorption, such as the hydrolysis of dietary phosphate esters, contributing to the regulation of phosphate metabolism. Its expression is upregulated in response to inflammation and microbial imbalance, acting as a protective mechanism against intestinal permeability and systemic endotoxemia. Additionally, ALPI prevents excessive immune activation by neutralizing pro-inflammatory signals, which is essential for preventing conditions such as inflammatory bowel disease (IBD) and sepsis. Alterations in ALPI expression or activity have been linked to gastrointestinal disorders, including Crohn's disease and ulcerative colitis. Its multifunctional role highlights its importance in gut health, immune modulation, and overall metabolic regulation.
Productos relacionados
Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody
ALPI Antibody is a Rabbit Polyclonal Antibody against ALPI.…
Ver producto
Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bon…
Ver producto
Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bon…
Ver producto