Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody
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935106861
info@markelab.com
Precio
175€ (20 µl)
Antibody anti-ALPI
proveedor
Abbexareference
abx006328Tested Applications
WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
ALPI Antibody is a Rabbit Polyclonal Antibody against ALPI.
Background
Intestinal-type alkaline phosphatase (ALPI) is a glycoprotein enzyme primarily expressed on the luminal surface of intestinal epithelial cells, particularly in the small intestine. It plays a crucial role in maintaining gut homeostasis by detoxifying lipopolysaccharides (LPS), dephosphorylating inflammatory mediators, and promoting a healthy microbiota. ALPI is also involved in nutrient absorption, such as the hydrolysis of dietary phosphate esters, contributing to the regulation of phosphate metabolism. Its expression is upregulated in response to inflammation and microbial imbalance, acting as a protective mechanism against intestinal permeability and systemic endotoxemia. Additionally, ALPI prevents excessive immune activation by neutralizing pro-inflammatory signals, which is essential for preventing conditions such as inflammatory bowel disease (IBD) and sepsis. Alterations in ALPI expression or activity have been linked to gastrointestinal disorders, including Crohn's disease and ulcerative colitis. Its multifunctional role highlights its importance in gut health, immune modulation, and overall metabolic regulation.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Intestinal-Type Alkaline Phosphatase / IAP (ALPI)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ALPI
dry ice
No
availability
Shipped within 5-10 working days.
alias
IAP
uniprot id
NCBI accession
NP_001622.2
note
This product is for research use only.
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