Corticotropin Releasing Hormone Receptor 1 (CRHR1) Antibody (FITC)
169€ (20 µg)
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Name
Corticotropin Releasing Hormone Receptor 1 (CRHR1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx106708
Description
CRHR1 Antibody (FITC) is a Rabbit Polyclonal antibody against CRHR1 conjugated to FITC. Recombinant Human CRHR1 ProteinG-Protein Coupled Receptor For Crh (CRH) And Ucn (Urocortin)Has High Affinity For Crh And UcnLigand Binding Causes A Conformation Change That Triggers Signaling Via Guanine Nucleotide-Binding Proteins (G Proteins) And Down-Stream Effectors, Such As Adenylate CyclasePromotes The Activation Of Adenylate Cyclase, Leading To Increased Intracellular Camp LevelsInhibits The Activity Of The Calcium Channel Cacna1HRequired For Normal Embryonic Development Of The Adrenal Gland And For Normal Hormonal Responses To StressPlays A Role In The Response To Anxiogenic Stimuli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Corticotropin Releasing Hormone Receptor 1 (CRHR1) Immunogen: Recombinant human Corticotropin-releasing factor receptor 1 protein (24-121AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P34998 |
| Gene ID | 104909134, 1394 |
| NCBI Accession | NP_001138618.1, NM_001145146.1 |
| Alias | CRHR1,CRFR1,CRF-R,CRHR,CRH-R1,CRF-R1alpha,CRF 1 receptor,CRF-RA,CRF1,CRF-R1,CRFR-1,CRHR1L |
| Background | Antibody anti-CRHR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CRHR1 is a G protein-coupled receptor (GPCR) that binds corticotropin-releasing hormone (CRH) and related peptides like urocortin 1, playing a central role in the hypothalamic-pituitary-adrenal (HPA) axis. CRHR1 is highly expressed in the brain, particularly in the hypothalamus, pituitary gland, and cerebral cortex, where it regulates stress responses by stimulating the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. Activation of CRHR1 triggers signaling pathways such as cAMP/PKA, MAPK, and calcium mobilization, leading to cellular responses that modulate stress, behavior, and emotional regulation. CRHR1 is implicated in stress-related disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), where dysregulated CRH signaling disrupts HPA axis activity and leads to chronic stress responses. CRHR1 also plays roles in energy metabolism, immune regulation, and inflammation, with emerging evidence linking it to conditions like obesity and inflammatory diseases. In cancer, CRHR1 overexpression has been observed in melanoma and other tumors, where CRH signaling promotes cell proliferation and survival. Pharmacological inhibitors of CRHR1, such as antagonists, are being explored as potential treatments for anxiety disorders, depression, and stress-induced metabolic dysfunctions, highlighting its importance in neuroendocrine regulation and disease.
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