Corticotropin Releasing Hormone Receptor 1 (CRHR1) Antibody

Product specifications

Primary Antibodies

Corticotropin Releasing Hormone Receptor 1 (CRHR1)

Rabbit

Human, Mouse, Rat

WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

≥ 95% (SDS-PAGE)

Purified by immunogen affinity chromatography.

100 µg

Liquid

ELISA, WB, IHC

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P34998

CRHR1,CRFR1,CRF-R,CRHR,CRH-R1,CRF-R1alpha,CRF 1 receptor,CRF-RA,CRF1,CRF-R1,CRFR-1,CRHR1L

Antibody anti-CRHR1

RUO

Concentration: 2 mg/ml - Validity: 12 months.

Descripción

CRHR1 is a G protein-coupled receptor (GPCR) that binds corticotropin-releasing hormone (CRH) and related peptides like urocortin 1, playing a central role in the hypothalamic-pituitary-adrenal (HPA) axis. CRHR1 is highly expressed in the brain, particularly in the hypothalamus, pituitary gland, and cerebral cortex, where it regulates stress responses by stimulating the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. Activation of CRHR1 triggers signaling pathways such as cAMP/PKA, MAPK, and calcium mobilization, leading to cellular responses that modulate stress, behavior, and emotional regulation. CRHR1 is implicated in stress-related disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), where dysregulated CRH signaling disrupts HPA axis activity and leads to chronic stress responses. CRHR1 also plays roles in energy metabolism, immune regulation, and inflammation, with emerging evidence linking it to conditions like obesity and inflammatory diseases. In cancer, CRHR1 overexpression has been observed in melanoma and other tumors, where CRH signaling promotes cell proliferation and survival. Pharmacological inhibitors of CRHR1, such as antagonists, are being explored as potential treatments for anxiety disorders, depression, and stress-induced metabolic dysfunctions, highlighting its importance in neuroendocrine regulation and disease.

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anti- CRHR1 antibody

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene.

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