Contactin 1 (CNTN1) Antibody
442€ (200 µl)
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Name
Contactin 1 (CNTN1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx431177
Tested Applications
P-ELISA, WB, IHC
Description
Contactin 1 Antibody is a Goat Polyclonal antibody against Contactin 1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Contactin 1 (CNTN1) Immunogen: abx617127 - Internal region, 585-870 AA: C-QVTSQEYSARLEN |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 1272, 12805, 117258 |
| NCBI Accession | NP_001834.2, NP_778203.1 |
| Alias | F3,GP135,MYPCN,CMYP12,Neural cell surface protein F3,Glycoprotein gp135,Contactin-1 |
| Background | Antibody anti-CNTN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Contactin 1 (CNTN1) is a neuronal cell adhesion molecule belonging to the immunoglobulin superfamily, playing a crucial role in nervous system development and maintenance. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in neurons, where it mediates axon guidance, neuronal migration, and synaptic formation. It interacts with other cell surface receptors such as the Notch and amyloid precursor protein (APP) signaling pathways, influencing neuronal differentiation and axon pathfinding. CNTN1 is also involved in the formation and stabilization of paranodal junctions in myelinated nerves by binding to Caspr and neurofascin, ensuring proper saltatory conduction. Dysregulation of CNTN1 has been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disabilities, as well as in autoimmune neuropathies like chronic inflammatory demyelinating polyneuropathy (CIDP). It has also been linked to cancer metastasis, with elevated levels associated with poor prognosis in certain tumors. Its extracellular immunoglobulin-like and fibronectin type III domains mediate homophilic and heterophilic interactions, making it an essential player in neuronal connectivity and signaling.
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