Complement receptor type 1 (CR1) Antibody
299€ (50 µl)
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935106861
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name
Complement receptor type 1 (CR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402376
tested applications
ELISA, IHC
Description
Complement receptor type 1 (CR1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human CR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Complement receptor type 1 (CR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17927 |
| Gene ID | 1378 |
| Alias | KN,C3BR,C4BR,CD35,Knops blood group,Complement receptor type 1,C3b/C4b receptor |
| Background | Antibody anti-CR1 |
| Status | RUO |
Descripción
CR1 (Complement Receptor 1), also known as CD35, is a membrane-bound glycoprotein that plays a key role in the immune system, primarily in mediating the clearance of immune complexes, apoptotic cells, and pathogens through its interaction with components of the complement system. CR1 acts as a receptor for complement proteins C3b and C4b, which are opsonins involved in the activation of the classical and alternative complement pathways. These pathways are critical for enhancing phagocytosis and immune complex clearance, ultimately contributing to host defense against infections. CR1 is expressed on a variety of immune cells, including erythrocytes (red blood cells), leukocytes, monocytes, macrophages, neutrophils, B cells, follicular dendritic cells, and kidney podocytes. The expression pattern of CR1 allows it to fulfill diverse immunological functions, such as regulating complement activation, promoting phagocytosis, and serving as a cofactor for complement cleavage and degradation.
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