Complement receptor type 1 (CR1) Antibody

Este producto es parte de CR1 - complement C3b/C4b receptor 1
Product Graph
299€ (50 µl)

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935106861
info@markelab.com
name
Complement receptor type 1 (CR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402376
tested applications
ELISA, IHC

Description

Complement receptor type 1 (CR1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human CR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Complement receptor type 1 (CR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG
Expression
Recombinant
Purification
Purified by affinity chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P17927
Gene ID
1378
Alias
KN,C3BR,C4BR,CD35,Knops blood group,Complement receptor type 1,C3b/C4b receptor
Background
Antibody anti-CR1
Status
RUO

Descripción

CR1 (Complement Receptor 1), also known as CD35, is a membrane-bound glycoprotein that plays a key role in the immune system, primarily in mediating the clearance of immune complexes, apoptotic cells, and pathogens through its interaction with components of the complement system. CR1 acts as a receptor for complement proteins C3b and C4b, which are opsonins involved in the activation of the classical and alternative complement pathways. These pathways are critical for enhancing phagocytosis and immune complex clearance, ultimately contributing to host defense against infections. CR1 is expressed on a variety of immune cells, including erythrocytes (red blood cells), leukocytes, monocytes, macrophages, neutrophils, B cells, follicular dendritic cells, and kidney podocytes. The expression pattern of CR1 allows it to fulfill diverse immunological functions, such as regulating complement activation, promoting phagocytosis, and serving as a cofactor for complement cleavage and degradation.

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