Complement Receptor Type 1 / CD35 (CR1) Antibody (PE)
429€ (100 tests)
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935106861
info@markelab.com
name
Complement Receptor Type 1 / CD35 (CR1) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx139373
tested applications
FCM
Description
CD35 Antibody is a Mouse Monoclonal against CD35.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Complement Receptor Type 1 / CD35 (CR1) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Clone ID | L881 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P17927 |
| Gene ID | 1378 |
| Alias | KN,C3BR,C4BR,CD35,Knops blood group,Complement receptor type 1,C3b/C4b receptor |
| Background | Antibody anti-CR1 |
| Status | RUO |
Descripción
CR1 (Complement Receptor 1), also known as CD35, is a membrane-bound glycoprotein that plays a key role in the immune system, primarily in mediating the clearance of immune complexes, apoptotic cells, and pathogens through its interaction with components of the complement system. CR1 acts as a receptor for complement proteins C3b and C4b, which are opsonins involved in the activation of the classical and alternative complement pathways. These pathways are critical for enhancing phagocytosis and immune complex clearance, ultimately contributing to host defense against infections. CR1 is expressed on a variety of immune cells, including erythrocytes (red blood cells), leukocytes, monocytes, macrophages, neutrophils, B cells, follicular dendritic cells, and kidney podocytes. The expression pattern of CR1 allows it to fulfill diverse immunological functions, such as regulating complement activation, promoting phagocytosis, and serving as a cofactor for complement cleavage and degradation.
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