Complement Receptor 2 / CD21 (CR2) Antibody (PerCP)
429€ (100 tests)
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Name
Complement Receptor 2 / CD21 (CR2) Antibody (PerCP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140554
Tested Applications
FCM
Description
Complement Receptor 2 / CD21 (CR2) Antibody (PerCP) is a Mouse Monoclonal against Complement Receptor 2 / CD21 (CR2).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Complement Receptor 2 / CD21 (CR2) Immunogen: IM9 human B-lymphoblastoid cell line |
| Host | Mouse |
| Reactivity | Human, Pig, Cow, Dog |
| Detection Method | Laser Line: 488 Excitation/Emission: 480/675 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PerCP |
| Isotype | IgG1 Kappa |
| Clone ID | F473 |
| Purification | The purified antibody is conjugated with PerCP under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P20023 |
| Gene ID | 1380 |
| Alias | CR,C3DR,CD21,CVID7,SLEB9,Complement receptor type 2,Complement C3d receptor,Epstein-Barr virus receptor,EBV receptor |
| Background | Antibody anti-CR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CR2, also known as complement receptor type 2 (CR2) or CD21, is a crucial protein involved in the immune response, particularly in the regulation and activation of B cells and the complement system. It serves as a receptor for fragments of complement component C3, specifically C3d, C3dg, and iC3b, which are breakdown products of C3b, an integral part of the complement system. By binding these complement fragments, CR2 plays a key role in amplifying the immune response and facilitating interactions between the innate and adaptive arms of the immune system. CR2 is predominantly expressed on the surface of B lymphocytes, follicular dendritic cells, and some epithelial cells. Its most well-known function is to enhance B-cell activation by linking the complement system to the B-cell receptor (BCR) signaling pathway. This enhances B-cell sensitivity to antigens, especially during the formation of immunological memory.
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