Complement Component 5a Receptor 1 (C5AR1) Antibody (PE)
520€ (100 tests)
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935106861
info@markelab.com
name
Complement Component 5a Receptor 1 (C5AR1) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx412921
tested applications
FCM
Description
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88) Antibody (PE) is a Mouse Monoclonal antibody against C5a Anaphylatoxin Chemotactic Receptor 1 (CD88).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Complement Component 5a Receptor 1 (C5AR1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 100 tests |
| Form | Lyophilized |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21730 |
| Alias | C5AR1,CD88,C5A,C5AR,C5R1,C5a anaphylatoxin chemotactic receptor,C5a-R,complement C5a receptor,complement component 5a receptor 1 |
| Background | Antibody anti-C5AR1 |
| Status | RUO |
Descripción
C5AR1 is a G protein-coupled receptor (GPCR) that binds C5a, a potent anaphylatoxin generated during complement activation, playing a key role in immune responses and inflammation. C5AR1 is primarily expressed on immune cells, including neutrophils, macrophages, eosinophils, and mast cells, where its activation triggers chemotaxis, degranulation, and the release of pro-inflammatory cytokines. The receptor mediates downstream signaling pathways, such as PI3K/Akt, MAPK, and NF-κB, promoting cell migration, survival, and inflammatory responses. C5AR1 is crucial for host defense, facilitating immune cell recruitment to sites of infection and tissue damage. However, dysregulated C5AR1 signaling contributes to excessive inflammation in diseases such as sepsis, rheumatoid arthritis, and asthma. In cancer, C5AR1 modulates the tumor microenvironment by promoting the recruitment of immunosuppressive myeloid cells, facilitating tumor growth and immune evasion. Additionally, C5AR1 activation has been implicated in neuroinflammation, contributing to neurodegenerative diseases like Alzheimer’s. Therapeutic targeting of C5AR1 with antagonists or inhibitors is being explored to treat inflammatory diseases, autoimmune disorders, and complement-driven cancers, aiming to reduce excessive inflammation and immune dysfunction.
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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a(PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events(PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production(PubMed:10636859, PubMed:15153520).
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