Colony Stimulating Factor 1 Receptor Phospho-Tyr809 (CSF1R pY809) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
Colony Stimulating Factor 1 Receptor Phospho-Tyr809 (CSF1R pY809) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx332862
tested applications
ELISA, IHC
Description
CSF1R (pY809) Antibody is a Rabbit Polyclonal against CSF1R (pY809).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Colony Stimulating Factor 1 Receptor Phospho-Tyr809 (CSF1R pY809) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr809 |
| Recommended Dilution | IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07333 |
| Gene ID | 1436 |
| Alias | Macrophage colony-stimulating factor 1 receptor,FMS,CSFR,FIM2,GPSC,HDLS,C-FMS,CD115,HDLS1,CSF-1R,BANDDOS,M-CSF-R,Proto-oncogene c-Fms,CSF-1 receptor |
| Background | Antibody anti-CSF1R |
| Status | RUO |
Descripción
The Colony Stimulating Factor 1 Receptor (CSF1R), also known as macrophage colony-stimulating factor receptor or CD115, is a cell surface receptor that primarily regulates the survival, proliferation, and differentiation of monocytes, macrophages, and osteoclasts. CSF1R is a transmembrane protein belonging to the receptor tyrosine kinase (RTK) family and is activated by binding to its primary ligand, colony-stimulating factor 1 (CSF1), as well as the alternative ligand interleukin-34 (IL-34). This receptor is essential for various immune functions and bone metabolism, primarily because of its role in maintaining and activating macrophage populations. The CSF1R gene is located on chromosome 5 (5q32) and encodes a protein that is essential in regulating macrophage differentiation, survival, and function. CSF1R signaling influences immune response, inflammation, tissue homeostasis, and bone remodeling. Dysregulation of CSF1R or its signaling pathways has been associated with pathological conditions such as inflammatory diseases, cancer, and neurodegenerative disorders. Furthermore, mutations in CSF1R have been implicated in a group of disorders characterized by leukoencephalopathy and early-onset neurodegeneration.
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