Coenzyme Q8B (COQ8B) Antibody (Biotin)

Este producto es parte de ADCK - aarF domain containing kinase
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169€ (20 µg)

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935106861
info@markelab.com
name
Coenzyme Q8B (COQ8B) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx316415
tested applications
ELISA

Description

ADCK4 Antibody (Biotin) is a Rabbit Polyclonal against ADCK4 conjugated to Biotin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Coenzyme Q8B (COQ8B)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q96D53
Gene ID
79934
NCBI Accession
NP_001136027.1, NM_001142555.2, NP_079152.3, NM_024876.3
OMIM
615567
Alias
NPHS9,COQ8B
Background
Antibody anti-ADCK4
Status
RUO

Descripción

aarF domain-containing kinase 4 (ADCK4), also known as COQ8B, is a mitochondrial protein involved in the biosynthesis and regulation of coenzyme Q10 (CoQ10), an essential molecule in the mitochondrial electron transport chain for ATP production. ADCK4 is particularly important in kidney and podocyte function, and mutations in the ADCK4 gene are associated with CoQ10 deficiency-related nephrotic syndrome, which can lead to kidney dysfunction and proteinuria. Beyond its role in mitochondrial bioenergetics, ADCK4 is thought to stabilize CoQ biosynthetic complexes, ensuring efficient electron transport and reducing oxidative stress. ADCK4 dysfunction is linked to mitochondrial diseases, with CoQ10 supplementation often used as a therapeutic strategy to mitigate symptoms and restore energy metabolism.
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