Atypical Kinase COQ8B, Mitochondrial (ADCK4) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Atypical Kinase COQ8B, Mitochondrial (ADCK4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013756
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against ADCK4 protein. Immunogen region is N-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Atypical Kinase COQ8B, Mitochondrial (ADCK4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96D53 |
| Alias | NPHS9,COQ8B |
| Background | Antibody anti-ADCK4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
aarF domain-containing kinase 4 (ADCK4), also known as COQ8B, is a mitochondrial protein involved in the biosynthesis and regulation of coenzyme Q10 (CoQ10), an essential molecule in the mitochondrial electron transport chain for ATP production. ADCK4 is particularly important in kidney and podocyte function, and mutations in the ADCK4 gene are associated with CoQ10 deficiency-related nephrotic syndrome, which can lead to kidney dysfunction and proteinuria. Beyond its role in mitochondrial bioenergetics, ADCK4 is thought to stabilize CoQ biosynthetic complexes, ensuring efficient electron transport and reducing oxidative stress. ADCK4 dysfunction is linked to mitochondrial diseases, with CoQ10 supplementation often used as a therapeutic strategy to mitigate symptoms and restore energy metabolism.
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