Coagulation Factor VIII (F8) Antibody

Description

F8, coagulation factor VIII, procoagulant component.This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa.This gene produces two alternatively spliced transcripts.Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex.This protein undergoes multiple cleavage events.Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc.This binding domain is essential for coagulant activity.Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.