CoActosin-Like Protein (COTL1) Antibody
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Description
CoActosin-Like Protein (COTL1) Antibody is a Rabbit polyclonal antibody for the detection of Human CoActosin-Like Protein (COTL1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CoActosin-Like Protein (COTL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14019 |
| Gene ID | 23406 |
| NCBI Accession | NP_066972.1 |
| Background | Antibody anti-COTL1 |
| Status | RUO |
Descripción
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COTL1 antibody
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
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Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5(5LO), influencing both its stability and activity in leukotrienes synthesis.
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