Cluster of Differentiation 81 (CD81) Antibody
292.5€ (80 µl)
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name
Cluster of Differentiation 81 (CD81) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032905
tested applications
ELISA, WB, IHC, FCM
Description
CD81 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cluster of Differentiation 81 (CD81) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P60033 |
| NCBI Accession | NP_004347.1 |
| Alias | CVID6,S5.7,CD81 antigen,26 kDa cell surface protein TAPA-1,Target of the antiproliferative antibody 1,Tetraspanin-28,Tspan-28, |
| Background | Antibody anti-CD81 |
| Status | RUO |
Descripción
CD81, also known as TAPA-1 (Target of the Anti-Proliferative Antibody 1), is a member of the tetraspanin family, a group of proteins that are widely expressed across various tissues and cell types. Tetraspanins are integral membrane proteins involved in a variety of biological processes, including cell adhesion, migration, proliferation, and signal transduction. CD81 has a well-established role in immune cell function, particularly in the regulation of B and T cell activity, as well as in viral infections. Most notably, CD81 is a critical component in the entry process of hepatitis C virus (HCV) into host cells. The CD81 gene is located on chromosome 11p15.5 and encodes a protein that is involved in the formation of tetraspanin-enriched microdomains. These microdomains facilitate the assembly of various signaling complexes at the cell membrane, influencing the function of associated proteins. CD81 is widely expressed on multiple cell types, including lymphocytes, hepatocytes, epithelial cells, and fibroblasts
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