Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) Antibody
494€ (200 µg)
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935106861
info@markelab.com
name
Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx414564
tested applications
ELISA, WB
Description
Tumor Necrosis Factor Ligand Superfamily Member 5 (CD154) Antibody is a Mouse Monoclonal antibody against Tumor Necrosis Factor Ligand Superfamily Member 5 (CD154).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 200 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29965 |
| Alias | T-cell antigen Gp39,IGM,IMD3,TRAP,gp39,CD154,CD40L,HIGM1,T-BAM,TNFSF5,hCD40L,TNF-related activation protein,Tumor necrosis factor ligand superfamily member 5 |
| Background | Antibody anti-CD40LG |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
CD40 ligand (CD40LG), also known as CD154 or TNFSF5, is a transmembrane protein expressed primarily on the surface of activated T cells and, to a lesser extent, on platelets and other cell types. It is a key member of the tumor necrosis factor (TNF) superfamily and functions as a ligand for CD40, a receptor found on the surface of various immune cells, including B cells, dendritic cells, macrophages, and endothelial cells. CD40LG-CD40 interactions are essential for effective immune responses, promoting T-cell-B-cell cooperation, antigen presentation, and the production of antibodies. Mutations in CD40LG are linked to X-linked hyper-IgM syndrome (XHIM), a primary immunodeficiency disorder, highlighting the protein's importance in immune system regulation. The CD40LG-CD40 axis also plays a role in the development of autoimmune diseases, cardiovascular disorders, and cancer, where the interaction is implicated in chronic inflammation and pathological immune activation.
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