Cluster of Differentiation 276 (CD276) Antibody
364€ (100 µg)
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935106861
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name
Cluster of Differentiation 276 (CD276) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240243
tested applications
ELISA, WB, IHC, IF/ICC
Description
Cluster of Differentiation 276 (CD276) Antibody is a Mouse Monoclonal antibody for the detection of B7H3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cluster of Differentiation 276 (CD276) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/300, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5ZPR3 |
| Gene ID | 80381 |
| OMIM | 605715 |
| Alias | B7H3,B7-H3,B7RP-2,4Ig-B7-H3,B7 homolog 3,Costimulatory molecule |
| Background | Antibody anti-CD276 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
CD276, also known as B7-H3, is a protein encoded by the CD276 gene located on chromosome 15q24.1. It is a member of the B7 family of immune regulatory molecules, which are known to play crucial roles in the modulation of immune responses. B7-H3 was first identified in 2001 and has since been recognized for its involvement in immune regulation, particularly in the context of cancer, autoimmunity, and transplantation. The expression of B7-H3 is widespread, found on various cell types, including dendritic cells, monocytes, activated T cells, and several non-immune cells such as fibroblasts, endothelial cells, and certain epithelial cells. Its expression can be induced by inflammatory cytokines and other immune signals.
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