Cluster Of Differentiation 14 (CD14) Antibody (APC / Cyanine 7)

Este producto es parte de CD14 - Cluster of Differentiation 14
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468€ (100 tests)

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935106861
info@markelab.com
name
Cluster Of Differentiation 14 (CD14) Antibody (APC / Cyanine 7)
category
Primary Antibodies
provider
Abbexa
reference
abx140969
tested applications
FCM

Description

Cluster Of Differentiation 14 (CD14) Antibody (APC / Cyanine 7) is a Mouse  against Cluster Of Differentiation 14 (CD14).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Cluster Of Differentiation 14 (CD14)
Host
Mouse
Reactivity
Human, Monkey
Conjugation
APC / Cyanine 7
Isotype
IgG1
Clone ID
Z327
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P08571
Gene ID
929
Alias
Cluster Of Differentiation 14,CD14,Myeloid Cell-Specific Leucine-Rich Glycoprotein,Monocyte differentiation antigen CD14
Background
Antibody anti-CD14
Status
RUO

Descripción

CD14 is a pattern recognition receptor (PRR) expressed on the surface of monocytes, macrophages, and neutrophils, where it plays a key role in the innate immune response CD14 functions as a co-receptor for the detection of lipopolysaccharides (LPS) derived from the outer membrane of Gram-negative bacteria It forms a complex with LPS-binding protein (LBP) and transduces signals via the Toll-like receptor 4 (TLR4)-MD2 complex, initiating downstream activation of nuclear factor kappa B (NF-κB) and subsequent production of pro-inflammatory cytokines CD14 exists in two forms, a membrane-bound form (mCD14) and a soluble form (sCD14), both of which contribute to LPS recognition and systemic inflammatory responses Dysregulation of CD14 signaling has been implicated in sepsis, chronic inflammatory diseases, and autoimmune disorders Elevated levels of soluble CD14 serve as a biomarker for monocyte activation in conditions such as HIV, cardiovascular disease, and metabolic disorders

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