Cleavage Stimulation Factor Subunit 3 (CSTF3) Antibody
416€ (200 µl)
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935106861
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name
Cleavage Stimulation Factor Subunit 3 (CSTF3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431742
tested applications
P-ELISA, WB
Description
CSTF3 Antibody is a Goat Polyclonal antibody against CSTF3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cleavage Stimulation Factor Subunit 3 (CSTF3) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 1479, 228410, 362178 |
| NCBI Accession | NP_001317.1 |
| Alias | CSTF-77,CF-1 77 kDa subunit,Cleavage stimulation factor 77 kDa subunit |
| Background | Antibody anti-CSTF3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Cleavage stimulation factor subunit 3 (CSTF3) is another essential element of the CstF complex, playing a vital role in 3' end cleavage and polyadenylation of pre-mRNAs, a process critical for mRNA maturation, stability, and export. CSTF3 functions as a homodimer and interacts with CSTF1 and CSTF2 to form the fully functional CstF complex, which participates in the recognition of cleavage sites on pre-mRNAs. It contains WD40 domains that facilitate protein-protein interactions, ensuring the stability and activity of the complex during the 3' end processing. CSTF3 is ubiquitously expressed across various tissues, highlighting its fundamental role in mRNA biogenesis. The CSTF3 gene undergoes alternative splicing, resulting in multiple transcript variants that encode different isoforms, potentially adapting its function to specific cellular contexts. CSTF3 not only participates in global mRNA processing but is also implicated in regulating alternative polyadenylation, which contributes to transcript diversity and gene expression regulation in response to developmental cues and external stimuli. Its broad expression and functional versatility emphasize its critical involvement in RNA metabolism.
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