Cleavage Stimulation Factor Subunit 2 Tau Variant (CSTF2T) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Cleavage Stimulation Factor Subunit 2 Tau Variant (CSTF2T) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx328831
tested applications
ELISA, WB, IHC
Description
CSTF2T Antibody is a Rabbit Polyclonal against CSTF2T.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cleavage Stimulation Factor Subunit 2 Tau Variant (CSTF2T) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H0L4 |
| Gene ID | 23283 |
| Alias | CstF-64T,CF-1 64 kDa subunit tau variant,TauCstF-64,Cleavage stimulation factor 64 kDa subunit tau variant |
| Background | Antibody anti-CSTF2T |
| Status | RUO |
Descripción
Cleavage stimulation factor subunit 2 tau variant (CSTF2T), also referred to as tauCstF-64, is a paralog of CSTF2 and functions in a tissue-specific manner, particularly in the germline. Unlike the ubiquitously expressed CSTF2, CSTF2T is primarily expressed in testis, particularly in pachytene spermatocytes and round spermatids, and is critical for spermatogenesis. It acts as a substitute for CSTF2 in male germ cells, ensuring the proper 3' end processing and polyadenylation of pre-mRNAs during meiosis. CSTF2T has a gene structure lacking introns, which may contribute to its tight regulation during spermatogenic development. Changes in CSTF2T expression have been linked to male infertility, as its deficiency disrupts germ cell-specific mRNA processing pathways required for proper sperm development. Research suggests that CSTF2T plays a role in maintaining RNA processing efficiency and alternative polyadenylation patterns necessary for male gamete formation and overall reproductive health.
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