Choline O-Acetyltransferase (CHAT) Antibody
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Description
Choline O-Acetyltransferase (CHAT) Antibody is a Rabbit polyclonal antibody for the detection of Human Choline O-Acetyltransferase (CHAT).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Choline O-Acetyltransferase (CHAT) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28329 |
| Gene ID | 1103 |
| NCBI Accession | NP_001136401.1 |
| Background | Antibody anti-CHAT |
| Status | RUO |
Descripción
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This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
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Catalyzes the reversible synthesis of acetylcholine(ACh) from acetyl CoA and choline at cholinergic synapses.
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