Chicken Melanocyte-Stimulating Hormone Receptor (MC1R) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for MC1R
proveedor
Abbexareference
abx555372Tested Applications
ELISAreactivity
Chickenstatus
RUOclonality
Descripción
Chicken Melanocyte-Stimulating Hormone Receptor (MC1R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Chicken Melanocyte-stimulating hormone receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
MC1R is a G protein-coupled receptor (GPCR) activated by melanocortin peptides, including α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). It is primarily expressed in melanocytes, where it regulates skin and hair pigmentation by stimulating the production of eumelanin (dark pigment) through the cAMP pathway. MC1R activation increases intracellular cyclic AMP (cAMP), activating protein kinase A (PKA) and leading to the upregulation of melanin synthesis. Variations and mutations in MC1R are associated with pigmentation phenotypes, such as red hair, fair skin, and an increased susceptibility to UV-induced skin damage and melanoma. Beyond pigmentation, MC1R plays roles in anti-inflammatory responses, immune modulation, and DNA repair, where its activation reduces inflammation and oxidative stress. MC1R agonists are being explored as therapeutic options for UV protection, melanoma prevention, and anti-inflammatory therapies. Its multifaceted role in pigmentation, inflammation, and cancer underscores MC1R’s significance as a therapeutic target.
Características del producto
category
ELISA Kits
immunogen target
Melanocyte-Stimulating Hormone Receptor (MC1R)
reactivity
Chicken
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
MC1R,CMM5,MSH-R,SHEP2,melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
MC1R
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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