Chemokine Like Receptor 1 (CMKLR1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Chemokine Like Receptor 1 (CMKLR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx146754
tested applications
ELISA, WB, IF/ICC
Description
Chemokine Like Receptor 1 (CMKLR1) Antibody is a Rabbit Polyclonal antibody for the detection of CMKLR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chemokine Like Receptor 1 (CMKLR1) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99788 |
| Gene ID | 1240 |
| OMIM | 602351 |
| Alias | CMKLR1,CHEMERINR,ChemR23,DEZ,ERV1,RVER1,chemokine receptor-like 1,Gpcr27,G-protein coupled receptor DEZ,resolvin E1 receptor,RVER1,tazarotene induced gene 2 receptor,TIG2 receptor |
| Background | Antibody anti-CMKLR1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
(CMKLR1), also known as ChemR23, is a G-protein-coupled receptor (GPCR) primarily activated by chemerin, a protein involved in immune responses and adipose tissue regulation. CMKLR1 is expressed in immune cells, such as macrophages, dendritic cells, and natural killer (NK) cells, as well as in adipocytes and smooth muscle cells. Its signaling plays a crucial role in inflammation and immune cell migration, especially during tissue injury or infection. CMKLR1 activation promotes macrophage recruitment to inflamed tissues, aiding in immune responses and wound healing. It also influences adipogenesis and metabolic regulation, contributing to energy balance and insulin sensitivity. CMKLR1 is implicated in cardiovascular diseases, where it regulates vascular inflammation and smooth muscle contraction, affecting blood pressure and vessel remodeling. Dysregulation of CMKLR1 signaling has been linked to metabolic disorders such as obesity, type 2 diabetes, and chronic inflammation. Moreover, CMKLR1 is being investigated as a target in autoimmune diseases and cancers, where its modulation could impact tumor microenvironments and immune evasion. The receptor's dual role in metabolic homeostasis and immune regulation positions it as a potential target for novel therapeutic interventions.
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