Chemokine Like Receptor 1 (CMKLR1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Chemokine Like Receptor 1 (CMKLR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031448
tested applications
ELISA, WB
Description
Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chemokine Like Receptor 1 (CMKLR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99788 |
| Alias | CMKLR1,CHEMERINR,ChemR23,DEZ,ERV1,RVER1,chemokine receptor-like 1,Gpcr27,G-protein coupled receptor DEZ,resolvin E1 receptor,RVER1,tazarotene induced gene 2 receptor,TIG2 receptor |
| Background | Antibody anti-CMKLR1 |
| Status | RUO |
Descripción
(CMKLR1), also known as ChemR23, is a G-protein-coupled receptor (GPCR) primarily activated by chemerin, a protein involved in immune responses and adipose tissue regulation. CMKLR1 is expressed in immune cells, such as macrophages, dendritic cells, and natural killer (NK) cells, as well as in adipocytes and smooth muscle cells. Its signaling plays a crucial role in inflammation and immune cell migration, especially during tissue injury or infection. CMKLR1 activation promotes macrophage recruitment to inflamed tissues, aiding in immune responses and wound healing. It also influences adipogenesis and metabolic regulation, contributing to energy balance and insulin sensitivity. CMKLR1 is implicated in cardiovascular diseases, where it regulates vascular inflammation and smooth muscle contraction, affecting blood pressure and vessel remodeling. Dysregulation of CMKLR1 signaling has been linked to metabolic disorders such as obesity, type 2 diabetes, and chronic inflammation. Moreover, CMKLR1 is being investigated as a target in autoimmune diseases and cancers, where its modulation could impact tumor microenvironments and immune evasion. The receptor's dual role in metabolic homeostasis and immune regulation positions it as a potential target for novel therapeutic interventions.
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