Chemokine C-X-C-Motif Receptor 4 (CXCR4) Antibody (PE)
546€ (100 tests)
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Name
Chemokine C-X-C-Motif Receptor 4 (CXCR4) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270804
Tested Applications
FCM
Description
Chemokine C-X-C-Motif Receptor 4 (CXCR4) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Chemokine C-X-C-Motif Receptor 4 (CXCR4) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Chemokine C-X-C-Motif Receptor 4 (CXCR4) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | CXCR4,CD184,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS,WHIMS1,fusin |
| Background | Antibody anti-CXCR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CXCR4 is a widely expressed G protein-coupled receptor that binds stromal cell-derived factor-1 (SDF-1/CXCL12), playing a key role in hematopoiesis, organ development, and immune cell trafficking. It is highly expressed on hematopoietic stem cells, lymphocytes, and endothelial cells. CXCR4 activation triggers pathways such as PI3K/Akt, MAPK, and JAK/STAT, promoting cell survival, migration, and proliferation. In the immune system, CXCR4 guides leukocyte migration to lymphoid tissues and inflammatory sites, facilitating immune surveillance. It is critical for embryonic development, particularly in the nervous, cardiovascular, and hematopoietic systems. In cancer, CXCR4 is overexpressed in many malignancies, including breast, lung, and pancreatic cancers, where it promotes tumor progression, metastasis, and angiogenesis by interacting with the CXCL12 gradient. CXCR4 also enhances the homing of cancer cells to distant organs, such as the bone marrow, contributing to metastasis and therapy resistance. In HIV infection, CXCR4 acts as a co-receptor for viral entry into T cells, playing a role in disease progression to AIDS. Targeting CXCR4 with antagonists like plerixafor is a therapeutic strategy for stem cell mobilization, HIV treatment, and anti-cancer therapy. Dysregulation of CXCR4 signaling is linked to inflammatory diseases, immune deficiencies, and metastatic cancer, highlighting its importance in immune regulation and disease pathogenesis.
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