Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody (Biotin)
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Description
CCRL2 Antibody (Biotin) is a Rabbit Polyclonal against CCRL2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00421 |
| Gene ID | 9034 |
| Alias | CCRL2,HCR,CKRX,CRAM,ACKR5,CRAM-A,CRAM-B,CCR11,Chemokine receptor X |
| Background | Antibody anti-CCRL2 |
| Status | RUO |
Descripción
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) is an atypical chemokine receptor that interacts with chemerin, a chemotactic protein, but does not exhibit classical signaling functions like other chemokine receptors. CCRL2 is primarily expressed on immune cells, such as macrophages, dendritic cells, and endothelial cells, as well as on cells within the tumor microenvironment. Unlike traditional chemokine receptors that trigger intracellular signaling cascades upon ligand binding, CCRL2 functions as a decoy receptor or scavenger receptor, binding to its ligand without inducing a signaling response. Instead, CCRL2 helps to regulate chemerin levels by presenting it to other functional receptors, such as CMKLR1. CCRL2 is essential for modulating immune responses during inflammation and plays a role in controlling the migration and activation of macrophages and natural killer (NK) cells in response to chemerin. Dysregulation of CCRL2 has been implicated in diseases such as asthma, rheumatoid arthritis, and cardiovascular inflammation, where it affects leukocyte trafficking and inflammatory cytokine production. In the context of cancer, CCRL2 expression is elevated in certain tumor types, where it helps recruit immune cells to the tumor microenvironment, potentially influencing tumor immunity and progression. As a non-signaling receptor, CCRL2 provides an additional layer of regulation for the chemokine network, balancing immune responses and inflammation. Its emerging roles in immunity, inflammation, and tumor biology make CCRL2 an attractive target for research and therapeutic development in inflammatory and oncological diseases.
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