Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324234
Tested Applications
ELISA, WB, IF/ICC
Description
CCRL2 Antibody is a Rabbit Polyclonal against CCRL2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Immunogen: Synthesized peptide derived from the Internal region of human CCRL2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00421 |
| Gene ID | 9034 |
| Alias | CCRL2,HCR,CKRX,CRAM,ACKR5,CRAM-A,CRAM-B,CCR11,Chemokine receptor X |
| Background | Antibody anti-CCRL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) is an atypical chemokine receptor that interacts with chemerin, a chemotactic protein, but does not exhibit classical signaling functions like other chemokine receptors. CCRL2 is primarily expressed on immune cells, such as macrophages, dendritic cells, and endothelial cells, as well as on cells within the tumor microenvironment. Unlike traditional chemokine receptors that trigger intracellular signaling cascades upon ligand binding, CCRL2 functions as a decoy receptor or scavenger receptor, binding to its ligand without inducing a signaling response. Instead, CCRL2 helps to regulate chemerin levels by presenting it to other functional receptors, such as CMKLR1. CCRL2 is essential for modulating immune responses during inflammation and plays a role in controlling the migration and activation of macrophages and natural killer (NK) cells in response to chemerin. Dysregulation of CCRL2 has been implicated in diseases such as asthma, rheumatoid arthritis, and cardiovascular inflammation, where it affects leukocyte trafficking and inflammatory cytokine production. In the context of cancer, CCRL2 expression is elevated in certain tumor types, where it helps recruit immune cells to the tumor microenvironment, potentially influencing tumor immunity and progression. As a non-signaling receptor, CCRL2 provides an additional layer of regulation for the chemokine network, balancing immune responses and inflammation. Its emerging roles in immunity, inflammation, and tumor biology make CCRL2 an attractive target for research and therapeutic development in inflammatory and oncological diseases.
Productos relacionados
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most clo…
Ver producto Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
CCRL2 Antibody is a Rabbit Polyclonal antibody against CCRL2.…
Ver producto
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
CCRL2 Antibody is a Rabbit Polyclonal against CCRL2.…
Ver producto