Chaperone Activity of Bc1 Complex-Like (CABC1) Antibody
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Description
CABC1 is one of several proteins for which expression is induced by p53 expression. The S. pombe homolog, ABC1, is a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chaperone Activity of Bc1 Complex-Like (CABC1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NI60 |
| Background | Antibody anti-CABC1 |
| Status | RUO |
Descripción
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This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.
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