Cell Adhesion Molecule 2 (CADM2) Antibody
52€ (10 µg)
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935106861
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name
Cell Adhesion Molecule 2 (CADM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013925
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against CADM2 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cell Adhesion Molecule 2 (CADM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N3J6 |
| Gene ID | 253559 |
| OMIM | 609938 |
| Alias | NECL3,IGSF4D,Necl-3,synCAM2,SynCAM 2,SynCAM-2,Synaptic cell adhesion molecule 2,Nectin-like protein 3,Immunoglobulin superfamily member 4D |
| Background | Antibody anti-CADM2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CADM2, also known as SynCAM2, is a neuronal cell adhesion molecule involved in synaptic organization, axon guidance, and neural circuit formation. It is predominantly expressed in the central nervous system, where it contributes to the development and maintenance of synaptic connections, particularly in excitatory synapses. CADM2 plays a critical role in long-term potentiation (LTP) and synaptic plasticity, processes essential for learning and memory. It also influences axonal growth and guidance by mediating interactions between neurons and glial cells. CADM2 has been implicated in neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia, where its dysregulation disrupts neural connectivity and cognitive function. Structurally, CADM2 contains extracellular immunoglobulin domains that mediate homophilic and heterophilic binding, enabling synaptic adhesion and signaling. It interacts with intracellular scaffolding proteins and signaling molecules to regulate cytoskeletal dynamics and intracellular signaling pathways. Beyond the nervous system, CADM2 is also expressed in reproductive tissues and has been linked to processes such as spermatogenesis. Emerging evidence suggests that CADM2 may influence metabolic regulation, with genetic variants associated with traits like body weight and energy expenditure.
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