CD59 Glycoprotein (CD59) Antibody (PE)
585€ (100 tests)
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Name
CD59 Glycoprotein (CD59) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270826
Tested Applications
FCM
Description
Protectin (CD59) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Protectin (CD59) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD59 Glycoprotein (CD59) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | CD59 blood group,1F5,EJ16,EJ30,EL32,G344,MIN1,MIN2,MIN3,MIRL,HRF20,MEM43,MIC11,MSK21,16.3A5,HRF-20,MAC-IP,CD59 glycoprotein,MAC-inhibitory protein,MAC-IP,Membrane attack complex inhibition factor,MACIF |
| Background | Antibody anti-CD59 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD59 molecule (CD59) is a small, glycosylphosphatidylinositol (GPI)-anchored protein expressed on the surface of a wide variety of human cells. Its primary function is to inhibit the formation of the membrane attack complex (MAC) during the complement cascade, which is part of the immune system’s defense mechanism. By binding to components C8 and C9 of the complement system, CD59 prevents the insertion and polymerization of MAC into cell membranes, protecting host cells from lysis. This protective role is critical in maintaining cellular integrity and preventing autoimmune damage. CD59 also exhibits roles beyond complement regulation; it has been implicated in modulating T-cell activation and participating in signal transduction pathways through its interactions with other membrane proteins. Deficiency or dysfunction of CD59 is associated with certain pathological conditions, such as paroxysmal nocturnal hemoglobinuria (PNH), where red blood cells become highly susceptible to complement-mediated lysis. Additionally, CD59 is being studied for its potential role in cancer, as its overexpression in tumor cells may help them evade immune surveillance. Its broad cellular expression and functional versatility make CD59 a crucial regulator of immune and cellular processes.
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