CD50 Antibody
299€ (0.1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
CD50 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139540
tested applications
IHC, FCM, FUNC
Description
CD50 Antibody is a Mouse Monoclonal against CD50.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD50 |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Clone ID | C254 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P32942 |
| Gene ID | 3385 |
| Alias | CD50,CDW50,ICAM-R,Intercellular adhesion molecule 3 |
| Background | Antibody anti-ICAM3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Intercellular Adhesion Molecule 3 (ICAM3), also known as CD50, is a member of the immunoglobulin superfamily (IgSF) that plays a crucial role in cell-cell adhesion and immune system regulation. It is expressed predominantly on leukocytes, especially resting lymphocytes, and interacts with integrins to mediate various immune responses, including leukocyte trafficking, T-cell activation, and antigen recognition. ICAM3 is particularly involved in the early stages of immune responses, functioning as a ligand for leukocyte function-associated antigen-1 (LFA-1), an integrin found on T cells and other leukocytes. ICAM-3 acts as a facilitator of immunological synapse formation, helping leukocytes adhere to antigen-presenting cells and promoting signaling pathways critical for immune activation. Its interaction with integrins also promotes adhesion between leukocytes and endothelial cells, an important step in the migration of immune cells to sites of inflammation or infection. ICAM-3 is essential in regulating leukocyte dynamics and activation during immune surveillance and host defense.
Related Products
Human ICAM-3(Intercellular adhesion molecule 3) ELISA Kit
Ver Producto
Mouse ICAM-3(intercellular adhesion molecule 3) ELISA Kit
Ver Producto
anti- ICAM3 antibody
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1(integrin alpha-L/beta-2)(PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages(PubMed:23775590).
Ver Producto