CD3e Molecule Associated Protein (CD3EAP) Antibody
292.5€ (80 µl)
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935106861
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name
CD3e Molecule Associated Protein (CD3EAP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031330
tested applications
ELISA, WB
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: CD3e Molecule Associated Protein (CD3EAP) Immunogen: KLH-conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human CD3EAP. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 55 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15446 |
| Alias | T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain |
| Background | Antibody anti-CD3E |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.
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