CD161 Antibody
429€ (100 tests)
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Name
CD161 Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140467
Tested Applications
FCM
Description
CD161 Antibody is a Mouse Monoclonal against CD161.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD161 Immunogen: Human NK cells. |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/660 |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 Kappa |
| Clone ID | Q157 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q12918 |
| Gene ID | 3820 |
| Alias | Killer cell lectin-like receptor subfamily B member 1,NKR,CD161,CLEC5B,NKR-P1,NKRP1A,NKR-P1A,hNKR-P1A,C-type lectin domain family 5 member B,Natural killer cell surface protein P1A |
| Background | Antibody anti-KLRB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Killer cell lectin-like receptor B1 (KLRB1), also known as CD161, is a type II transmembrane protein predominantly expressed on subsets of immune cells, especially natural killer (NK) cells and T cells. KLRB1 plays a key role in modulating immune responses and is especially involved in the regulation of cytotoxicity and cytokine production, particularly among NK and T cell subsets. KLRB1 belongs to the C-type lectin superfamily and is encoded by the KLRB1 gene located on chromosome 12p13 in humans. KLRB1’s expression is associated with an inhibitory effect on immune cell activation, helping maintain immune homeostasis, prevent excessive immune responses, and aid in the modulation of immune activity against infections, tumors, and in inflammatory diseases. KLRB1 is primarily known for its role as a receptor for the carbohydrate-bearing protein LLT1 (lectin-like transcript 1, or CLEC2D). This interaction facilitates cell-cell communication and can mediate inhibitory signaling in NK cells and some T cell subsets, potentially leading to immune tolerance in certain tissues and tumors.
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