CD161 Antibody

Este producto es parte de KLRB1 - killer cell lectin like receptor B1
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429€ (100 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
CD161 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140467
tested applications
FCM

Description

CD161 Antibody is a Mouse Monoclonal against CD161.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
CD161
Host
Mouse
Reactivity
Human, Monkey
Recommended Dilution
FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
APC
Isotype
IgG1 Kappa
Clone ID
Q157
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
Q12918
Gene ID
3820
Alias
Killer cell lectin-like receptor subfamily B member 1,NKR,CD161,CLEC5B,NKR-P1,NKRP1A,NKR-P1A,hNKR-P1A,C-type lectin domain family 5 member B,Natural killer cell surface protein P1A
Background
Antibody anti-KLRB1
Status
RUO

Descripción

Killer cell lectin-like receptor B1 (KLRB1), also known as CD161, is a type II transmembrane protein predominantly expressed on subsets of immune cells, especially natural killer (NK) cells and T cells. KLRB1 plays a key role in modulating immune responses and is especially involved in the regulation of cytotoxicity and cytokine production, particularly among NK and T cell subsets. KLRB1 belongs to the C-type lectin superfamily and is encoded by the KLRB1 gene located on chromosome 12p13 in humans. KLRB1’s expression is associated with an inhibitory effect on immune cell activation, helping maintain immune homeostasis, prevent excessive immune responses, and aid in the modulation of immune activity against infections, tumors, and in inflammatory diseases. KLRB1 is primarily known for its role as a receptor for the carbohydrate-bearing protein LLT1 (lectin-like transcript 1, or CLEC2D). This interaction facilitates cell-cell communication and can mediate inhibitory signaling in NK cells and some T cell subsets, potentially leading to immune tolerance in certain tissues and tumors.

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