CD154 Antibody
123.5€ (25 µg)
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935106861
info@markelab.com
name
CD154 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx229148
tested applications
FCM, IP
Description
CD154 Antibody is a Human,Monkey Monoclonal Antibody against CD154.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD154 |
| Host | Mouse |
| Reactivity | Human,Monkey |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 25 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Tested Applications | FCM, IP |
| Buffer | 0.2 µm filtered in PBS, pH7.2. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P29965 |
| Gene ID | 959 |
| Alias | T-cell antigen Gp39,IGM,IMD3,TRAP,gp39,CD154,CD40L,HIGM1,T-BAM,TNFSF5,hCD40L,TNF-related activation protein,Tumor necrosis factor ligand superfamily member 5 |
| Background | Antibody anti-CD40LG |
| Status | RUO |
Descripción
CD40 ligand (CD40LG), also known as CD154 or TNFSF5, is a transmembrane protein expressed primarily on the surface of activated T cells and, to a lesser extent, on platelets and other cell types. It is a key member of the tumor necrosis factor (TNF) superfamily and functions as a ligand for CD40, a receptor found on the surface of various immune cells, including B cells, dendritic cells, macrophages, and endothelial cells. CD40LG-CD40 interactions are essential for effective immune responses, promoting T-cell-B-cell cooperation, antigen presentation, and the production of antibodies. Mutations in CD40LG are linked to X-linked hyper-IgM syndrome (XHIM), a primary immunodeficiency disorder, highlighting the protein's importance in immune system regulation. The CD40LG-CD40 axis also plays a role in the development of autoimmune diseases, cardiovascular disorders, and cancer, where the interaction is implicated in chronic inflammation and pathological immune activation.
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