CD127 Antibody (FITC)

Este producto es parte de IL7R - interleukin 7 receptor
Product Graph
130€ (50 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
CD127 Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx228260
tested applications
FCM

Description

CD127 Antibody (FITC) is a Mouse Monoclonal Antibody against CD127.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
CD127
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Conjugation
FITC
Isotype
IgG2a
Size 1
50 tests
Size 2
100 tests
Size 3
200 tests
Tested Applications
FCM
Buffer
PBS with 0.05% Proclin300, 1% BSA.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P16872
Gene ID
16197
Alias
Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA
Background
Antibody anti-IL7R
Status
RUO

Descripción

The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.

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