IL7R antibody

Este producto es parte de IL7R - interleukin 7 receptor
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935106861
info@markelab.com
name
IL7R antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01415
tested applications
ELISA, WB, FC, IP

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
interleukin 7 receptor (IL7R)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
56-58 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, FC, IP
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P16871
Gene ID
3575
Alias
Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA
Background
Antibody anti-IL7R
Status
RUO
Note
Mol. Weight 56-58 kDa

The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.

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