CD11b Antibody (PE / Cyanine 5)

Este producto es parte de ITGAM - integrin subunit alpha M
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130€ (20 tests)

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935106861
info@markelab.com
name
CD11b Antibody (PE / Cyanine 5)
category
Primary Antibodies
provider
Abbexa
reference
abx229270
tested applications
FCM

Description

CD11b Antibody (PE / Cyanine 5) is a Human Monoclonal Antibody against CD11b.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
CD11b
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
PE / Cyanine 5
Isotype
IgG1 Kappa
Size 1
20 tests
Size 2
100 tests
Size 3
200 tests
Tested Applications
FCM
Buffer
PBS with 0.05% Proclin300, 1% BSA.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P11215
Gene ID
3684
Alias
CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor
Background
Antibody anti-ITGAM
Status
RUO

Descripción

Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.

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